2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

Base Information

Chemical Name:2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one
CAS No.:1417562-29-8
Molecular Formula:C₂₂H₂₁FN₄O
Molecular Weight:376.433
Hs Code.:

Synonyms:2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

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Chemical Property of 2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

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Technology Process of 2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

There total 4 articles about 2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1417561-70-6
2-[4-(4-fluorophenyl)piperazine-1-carbonyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

: 1417562-29-8
2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

: 59661-51-7
5-oxo-4,5-dihydropyrrolo[1,2-a]quinazoline-2-carbonitrile

: 1417562-29-8
2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / water / 4 h / 100 °C

2: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); hydrogen bromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 59661-20-0
(E,Z)-2-(2,3-dicyanopropen-1-ylamino)benzoic acid methyl ester

: 1417562-29-8
2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]pyrrolo[1,2-a]quinazolin-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 2 h / 20 °C

2: hydrogen bromide / water / 4 h / 100 °C

3: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); hydrogen bromide; sodium ethanolate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;