(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Base Information

Chemical Name:(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
CAS No.:148533-52-2
Molecular Formula:C₂₃H₂₈NO₅P
Molecular Weight:429.453
Hs Code.:

Synonyms:(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

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Chemical Property of (1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

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Technology Process of (1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

There total 4 articles about (1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 50972-25-3
C₁₃H₁₂ClO₂P

: 7143-09-1
methyl ecgonine

: 148533-52-2
(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm400228w

Reference yield:

: 53-21-4
(-)-cocaine hydrochloride

: 148533-52-2
(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.25M aq. HCl / Heating

2: HCl

3: LDA

With hydrogenchloride; lithium diisopropyl amide;
DOI:10.1016/S0960-894X(00)00659-4

Reference yield:

: 824-72-6
P,P-dichlorophenylphosphine oxide

: 148533-52-2
(1R,2R,3S,5S)-methyl 3-(((benzyloxy)(phenyl)phosphoryl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N

1.2: PCl₅ / CHCl₃

2.1: LDA

With triethylamine; lithium diisopropyl amide;
DOI:10.1016/S0960-894X(00)00659-4