(-)-tamandarin B

Base Information

Chemical Name:(-)-tamandarin B
CAS No.:258339-38-7
Molecular Formula:C₅₃H₈₃N₇O₁₄
Molecular Weight:1042.28
Hs Code.:

Synonyms:(-)-tamandarin B

Suppliers and Price of (-)-tamandarin B

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Chemical Property of (-)-tamandarin B

Chemical Property:

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Technology Process of (-)-tamandarin B

There total 21 articles about (-)-tamandarin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1685-33-2
N-[(benzyloxy)carbonyl]-D-valine

: 258339-38-7
(-)-tamandarin B

Guidance literature:: Multi-step reaction with 14 steps

1: 95 percent / EDAC*HCl; DMAP / CH₂Cl₂ / 0 - 20 °C

2: 83 percent / tetrahydrofuran / -78 °C

3: 77 percent / potassium borohydride / methanol / -30 - 0 °C

4: 82 percent / 2,6-lutidine / CH₂Cl₂ / 20 °C

5: 81 percent / aq. NaOH / tetrahydrofuran; methanol / 0 - 20 °C

6: 60 percent / EDAC*HCl; DMAP / CH₂Cl₂ / 0 - 20 °C

7: 100 percent / Pd(PPh₃)4; morpholine / tetrahydrofuran / 20 °C

8: Pyr / CH₂Cl₂

9: 79 percent / DIEA; DMAP / CH₂Cl₂ / 0 - 20 °C

10: MgBr₂*Et₂O / CH₂Cl₂ / -15 - 0 °C

11: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

12: HATU; DIEA / dimethylformamide / 20 °C

13: HCl(g) / ethyl acetate / -30 - 0 °C

14: 0.0065 g / DEPBT; DIEA / CH₂Cl₂ / 15 h / 20 °C

With morpholine; pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium borohydride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja010222c

Reference yield:

: 126587-61-9
Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine-OSEM

: 258339-38-7
(-)-tamandarin B

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / Pd/C / methanol; ethyl acetate / 5 h

2: 79 percent / DIEA; DMAP / CH₂Cl₂ / 0 - 20 °C

3: MgBr₂*Et₂O / CH₂Cl₂ / -15 - 0 °C

4: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

5: HATU; DIEA / dimethylformamide / 20 °C

6: HCl(g) / ethyl acetate / -30 - 0 °C

7: 0.0065 g / DEPBT; DIEA / CH₂Cl₂ / 15 h / 20 °C

With hydrogenchloride; dmap; hydrogen; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja010222c

Reference yield:

: 178113-56-9
L-2-hydroxy-3-methylbutanoic acid allyl ester

: 258339-38-7
(-)-tamandarin B

Guidance literature:: Multi-step reaction with 9 steps

1: 60 percent / EDAC*HCl; DMAP / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / Pd(PPh₃)4; morpholine / tetrahydrofuran / 20 °C

3: Pyr / CH₂Cl₂

4: 79 percent / DIEA; DMAP / CH₂Cl₂ / 0 - 20 °C

5: MgBr₂*Et₂O / CH₂Cl₂ / -15 - 0 °C

6: H₂ / Pd/C / ethyl acetate; methanol / 20 °C

7: HATU; DIEA / dimethylformamide / 20 °C

8: HCl(g) / ethyl acetate / -30 - 0 °C

9: 0.0065 g / DEPBT; DIEA / CH₂Cl₂ / 15 h / 20 °C

With morpholine; pyridine; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja010222c