(2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate

Base Information

• Chemical Name: (2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate
• CAS No.: 1131220-43-3
• Molecular Formula: C₁₆H₂₂N₂O₄
• Molecular Weight: 306.362
• Mol file: 1131220-43-3.mol

Synonyms:(2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate

Chemical Property of (2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of (2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate

There total 1 articles about (2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-4-(4-(tert-butoxycarbonyl)morpholin-2-yl)benzoic acid (1131220-40-0) → (2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate (1131220-43-3)

Guidance literature:

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield: 86.0%

(2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate (1131220-43-3) + acetic acid (64-19-7,77671-22-8) → (2S)-tert-butyl 2-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)morpholine-4-carboxylate (1131220-46-6)

Guidance literature:

(2S)-tert-butyl 2-(4-carbamoylphenyl)morpholine-4-carboxylate; With N,N-dimethylacetamide dimethyl acetal; at 100 ℃; for 1h;

acetic acid; With sodium hydroxide; hydroxylamine hydrochloride; In 1,4-dioxane; water; at 100 ℃; for 2h;

upstream raw materials:

(S)-4-(4-(tert-butoxycarbonyl)morpholin-2-yl)benzoic acid

Downstream raw materials:

(2S)-tert-butyl 2-(4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl)morpholine-4-carboxylate