Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester

Base Information

• Chemical Name: Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester
• CAS No.: 137718-68-4
• Molecular Formula: C₃₀H₄₂N₂O₈S₂
• Molecular Weight: 622.804

Synonyms:Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester

Chemical Property of Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester

There total 5 articles about Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester (137718-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 24 h / Heating

2: 1.) NaH / 2.) DMF, 0 deg C, 12 h

With pyridine; sodium hydride; In dichloromethane;

DOI:10.1021/ja00025a035

Reference yield:

N-(allylglycinoyl)-(1R,2S)-bornane-10,2-sultam (137819-69-3) → Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester (137718-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 24 h / Heating

2: 1.) NaH / 2.) DMF, 0 deg C, 12 h

With pyridine; sodium hydride; In dichloromethane;

DOI:10.1021/ja00025a035

Reference yield:

(2R)-N-{N-[bis(methylthio)methylidene]glycyl}bornane-10,2-sultam (127556-03-0,137819-66-0) → Carbonic acid (Z)-4-[[(R)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-but-3-enyl]-(2,4,6-trimethyl-benzenesulfonyl)-amino]-but-2-enyl ester methyl ester (137718-68-4)

Guidance literature:

Multi-step reaction with 4 steps

1: LiOH, Bu₄NHSO₄ / CH₂Cl₂; H₂O / 0.1 h / -7 °C / Irradiation

2: 0.5N HCl / tetrahydrofuran; H₂O / 4 h / Ambient temperature

3: pyridine / CH₂Cl₂ / 24 h / Heating

4: 1.) NaH / 2.) DMF, 0 deg C, 12 h

With pyridine; hydrogenchloride; lithium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ja00025a035

upstream raw materials:

N-[(R)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-but-3-enyl]-2,4,6-trimethyl-benzenesulfonamide

(Z)-1-bromo-4<(methoxycarbonyl)oxy>-2-butene

2-mesitylenesulphonyl chloride

N-(allylglycinoyl)-(1R,2S)-bornane-10,2-sultam

Downstream raw materials:

(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methyl-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

(3R,4aR,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-7-methylene-2-(2,4,6-trimethyl-benzenesulfonyl)-octahydro-[2]pyrindin-6-one

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