N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

Base Information

Chemical Name:N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide
CAS No.:1418024-09-5
Molecular Formula:C₂₅H₂₁ClN₂O₄
Molecular Weight:448.906
Hs Code.:

Synonyms:N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

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Chemical Property of N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

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Technology Process of N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

There total 9 articles about N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1418025-85-0
3-aminomethyl-7-chloro-1-phenyl-1H-quinolin-4-one

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 1418024-09-5
N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

Guidance literature:: 3-aminomethyl-7-chloro-1-phenyl-1H-quinolin-4-one; 3,4-dimethoxybenzoic acid chloride; In dichloromethane; at 0 ℃; for 0.25h; under 760.051 Torr; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418024-09-5
N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: dichloromethane / 0.25 h / 0 °C / 760.05 Torr / Inert atmosphere

6.2: 1 h / 0 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418024-09-5
N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

1.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: dichloromethane / 0.25 h / 0 °C / 760.05 Torr / Inert atmosphere

5.2: 1 h / 0 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;