3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide

Base Information

• Chemical Name: 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide
• CAS No.: 60632-18-0
• Molecular Formula: C₁₅H₂₃NO₂
• Molecular Weight: 249.353
• Mol file: 60632-18-0.mol

Synonyms:3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide

Chemical Property of 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide

Chemical Property:

• Melting Point: >170°C (dec.)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Ethanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3,5-Di-tert-butyl-4-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3,5-Di-tert-butyl-4-hydroxybenzamide is used in the preparation of 2-(3,5-di-tert-butyl-4-hydroxyphenyl)oxazoles as anti-atherosclerotic agents.

Technology Process of 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide

There total 6 articles about 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

3,5-Di-tert-butyl-4-hydroxybenzoic acid (1421-49-4) → 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide (60632-18-0)

Guidance literature:

With hydrogenchloride; ammonia; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

sodium 3,5-di-tert-butyl-4-hydroxy-benzoate → 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide (60632-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / petroleum ether

2: aq. NH₃, Py

With pyridine; ammonium hydroxide; thionyl chloride; In Petroleum ether;

Reference yield:

3,5-di-tert-butyl-4-hydroxybenzoyl chloride (40056-43-7) → 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzamide (60632-18-0)

Guidance literature:

With pyridine; ammonium hydroxide;

upstream raw materials:

2,6-di-tert-butyl-4-cyanophenol

3,5-di-tert-butyl-4-hydroxybenzoyl chloride

3,5-di-tert-butyl-4-hydroxybenzaldehyde oxime

3,5-Di-tert-butyl-4-hydroxybenzoic acid

Downstream raw materials:

2,6-di-tert-butyl-4-cyanophenol

5-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-[1,3,4]oxathiazol-2-one