(S)-2-methylazetidine

Base Information

• Chemical Name: (S)-2-methylazetidine
• CAS No.: 52265-79-9
• Molecular Formula: C₄H₉N
• Molecular Weight: 71.1222
• Mol file: 52265-79-9.mol

Synonyms:(S)-2-methylazetidine

Chemical Property of (S)-2-methylazetidine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methylazetidine

There total 1 articles about (S)-2-methylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-4-aminobutan-2-ol → (S)-2-methylazetidine (52265-79-9) + (R)-2-methylazetidine (35848-07-8)

Guidance literature:

Yield given; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo981901h

Reference yield:

tert-butyl (1S,3R,5S)-3-(3-(5-fluoro-3-iodoquinoline-8-carboxamido)pyridin-4-yl)-5-methylcyclohexylcarbamate + (S)-2-methylazetidine (52265-79-9) → N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-5-fluoro-3-((S)-2-methylazetidin-1-yl)quinoline-8-carboxamide

Guidance literature:

tert-butyl (1S,3R,5S)-3-(3-(5-fluoro-3-iodoquinoline-8-carboxamido)pyridin-4-yl)-5-methylcyclohexylcarbamate; (S)-2-methylazetidine; With chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation; caesium carbonate; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;