bis-di-tert-butyl methyl phosphate

Base Information

• Chemical Name: bis-di-tert-butyl methyl phosphate
• CAS No.: 427899-56-7
• Molecular Formula: C₁₇H₃₈O₈P₂
• Molecular Weight: 432.431
• Mol file: 427899-56-7.mol

Synonyms:bis-di-tert-butyl methyl phosphate

Chemical Property of bis-di-tert-butyl methyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bis-di-tert-butyl methyl phosphate

There total 5 articles about bis-di-tert-butyl methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Chloroiodomethane (593-71-5) + tetramethylammonium di-tert-butyl hydrogen phsophate (34075-24-6) → di-tert-butyl chloromethyl phosphate (229625-50-7) + bis-di-tert-butyl methyl phosphate (427899-56-7)

Guidance literature:

In 1,2-dimethoxyethane; at 85 ℃; for 1.5h; Heating / reflux;

Reference yield:

Chloroiodomethane (593-71-5) + phosphoric acid di-tert-butyl ester (33494-81-4) → di-tert-butyl chloromethyl phosphate (229625-50-7) + bis-di-tert-butyl methyl phosphate (427899-56-7)

Guidance literature:

phosphoric acid di-tert-butyl ester; With tetramethyl ammoniumhydroxide; In water; acetone; Cooling with ice bath;

Chloroiodomethane; In 1,2-dimethoxyethane; for 1h; Heating / reflux;

Reference yield:

potassium di-tert-butylphosphate (33494-80-3) + iodomethyl 4-methylbenzenesulfonate (117184-52-8) → di-tert-butyl iodomethyl phosphate (1273191-44-8) + di-tert-butyl (p-toluenesulfonylmethyl) phosphate (1596347-54-4) + bis-di-tert-butyl methyl phosphate (427899-56-7)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tetrahydrofuran; at 0 ℃; for 7h; Solvent; Inert atmosphere;

DOI:10.1021/op500066f

upstream raw materials:

Chloroiodomethane

tetramethylammonium di-tert-butyl hydrogen phsophate

phosphoric acid di-tert-butyl ester

di-tert-butyl phosphite

Downstream raw materials:

di-tert-butyl chloromethyl phosphate

Refernces

• 1、 -. "PRODRUGS AND METHODS OF MAKING AND USING THE SAME". Page/Page column 63-64. . Retrieved 2008/12/06.
• 2、 Krise, Jeffrey P.,Zygmunt, Jan,Georg, Gunda I.,Stella, Valentino J.. "Novel prodrug approach for tertiary amines: Synthesis and preliminary evaluation of N-phosphonooxymethyl prodrugs". . p. 3094 - 3100. Retrieved 2007/10/03.