N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

Base Information

Chemical Name:N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide
CAS No.:1309165-06-7
Molecular Formula:C₂₈H₃₈ClFN₂O₅S
Molecular Weight:569.138
Hs Code.:

Synonyms:N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

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Chemical Property of N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

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Technology Process of N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

There total 4 articles about N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309166-57-1
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-3-chloro-4-fluoro-N-isobutylbenzenesulfonamide

: 220876-16-4
1-(methoxymethyl)cyclopentanecarboxylic acid

: 1309165-06-7
N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 3400-45-1
cyclopentanecarboxylic acid

: 1309165-06-7
N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 6 h / 80 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere

2.2: -75 - 20 °C / Inert atmosphere

3.1: potassium hydroxide; ethanol / 6 h / 80 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

With n-butyllithium; ethanol; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 5453-85-0
ethyl cyclopentanecarboxylate

: 1309165-06-7
N-((2S,3R)-4-(3-chloro-4-fluoro-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-1-(methoxymethyl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere

1.2: -75 - 20 °C / Inert atmosphere

2.1: potassium hydroxide; ethanol / 6 h / 80 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 20 °C

With n-butyllithium; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane;