2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

Base Information

Chemical Name:2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole
CAS No.:1435489-12-5
Molecular Formula:C₂₄H₂₀N₄O
Molecular Weight:380.449
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

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Chemical Property of 2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

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Technology Process of 2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

There total 6 articles about 2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1120-87-2
4-bromopyridin

: 1435488-88-2
2-(4-methoxyphenyl)-1-methyl-6-phenyl-1H-imidazo[1,2-b]pyrazole

: 1435489-12-5
2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: With palladium acetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 160 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/chem.201202593

Reference yield: 81.0%

: 626-61-9
4-Chloropyridine

: 1435488-88-2
2-(4-methoxyphenyl)-1-methyl-6-phenyl-1H-imidazo[1,2-b]pyrazole

: 1435489-12-5
2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: With palladium acetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 160 ℃; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/chem.201202593

Reference yield:

: 827-41-8
3-phenylpyrazol-5-amine

: 1435489-12-5
2-(4-methoxyphenyl)-1-methyl-6-phenyl-3-(pyridin-4-yl)-1H-imidazo[1,2-b]pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / acetonitrile / 24 h / 40 °C

2: hydrogenchloride / water; ethanol / 24 h / 20 °C

3: sodium hydride; methyl iodide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

4: palladium acetate; potassium carbonate; tricyclohexylphosphine / 1,4-dioxane / 1 h / 160 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; palladium acetate; sodium hydride; sodium carbonate; potassium carbonate; tricyclohexylphosphine; methyl iodide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201202593