{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

Base Information

Chemical Name:{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal
CAS No.:198407-86-2
Molecular Formula:C₂₄H₂₈O₃Si
Molecular Weight:392.57
Hs Code.:

Synonyms:{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

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Chemical Property of {2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

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Technology Process of {2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

There total 8 articles about {2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 198407-84-0
2-{3-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-1-ynyl}-cyclohex-2-enone

: 198407-86-2
{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1016/S0040-4039(97)10010-7

Reference yield:

: 26260-02-6
2-iodobenzaldehyde

: 198407-86-2
{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / tetrahydrofuran / 14 h / -60 °C

2: 86 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

3: 74 percent / Pd(PPh₃)2Cl₂, CuI, HN(iPr)2 / tetrahydrofuran / 24 h / Ambient temperature

4: 78 percent / Pd₂dba3*CHCl₃, CuI, NEt₃, tris(2-furyl)phosphine / tetrahydrofuran / 1 h / Ambient temperature

5: 78 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / Ambient temperature

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; trifuran-2-yl-phosphane; Dess-Martin periodane; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(97)10010-7

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 198407-86-2
{2-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(6-oxo-cyclohex-1-enyl)-prop-2-ynyl]-phenyl}-propynal

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / PDC / CH₂Cl₂ / 12 h / Ambient temperature

2: 86 percent / tetrahydrofuran / 14 h / -60 °C

3: 86 percent / imidazole / CH₂Cl₂ / 12 h / Ambient temperature

4: 74 percent / Pd(PPh₃)2Cl₂, CuI, HN(iPr)2 / tetrahydrofuran / 24 h / Ambient temperature

5: 78 percent / Pd₂dba3*CHCl₃, CuI, NEt₃, tris(2-furyl)phosphine / tetrahydrofuran / 1 h / Ambient temperature

6: 78 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / Ambient temperature

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; dipyridinium dichromate; trifuran-2-yl-phosphane; Dess-Martin periodane; triethylamine; diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(97)10010-7