2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester
• CAS No.: 1187201-16-6
• Molecular Formula: C₂₀H₂₀BrNO₂
• Molecular Weight: 386.288
• Mol file: 1187201-16-6.mol

Synonyms:2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester

Chemical Property of 2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester

There total 1 articles about 2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

allyl-[1-(2-bromophenyl)-pent-4-enyl]-carbamic acid benzyl ester (1187201-15-5) → 2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester (1187201-16-6)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2009.05.009

Reference yield: 57.0%

2-(2-bromophenyl)-2,3,4,7-tetrahydroazepine-1-carboxylic acid benzyl ester (1187201-16-6) → 12-azatricyclo[6.3.2.0(2,7)]trideca-2(7),3,5,9-tetraene-12-carboxylic acid benzyl ester (1187201-17-7) + 12-azatricyclo-[6.3.2.0(2,7)]trideca-2(7),3,5,9-tetraene-12-carboxylic acid benzyl ester (1187201-18-8)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2009.05.009

upstream raw materials:

allyl-[1-(2-bromophenyl)-pent-4-enyl]-carbamic acid benzyl ester

Downstream raw materials:

12-azatricyclo[6.3.2.0(2,7)]trideca-2⁽⁷⁾,3,5,9-tetraene-12-carboxylic acid benzyl ester

12-azatricyclo-[6.3.2.0(2,7)]trideca-2⁽⁷⁾,3,5,9-tetraene-12-carboxylic acid benzyl ester