Fadrozole

Base Information

Chemical Name:Fadrozole
CAS No.:102676-47-1
Molecular Formula:C₁₄H₁₃N₃
Molecular Weight:223.277
Hs Code.:2933990090
European Community (EC) Number:862-508-6
UNII:H3988M64PU
DSSTox Substance ID:DTXSID5034141
Nikkaji Number:J366.696D
Wikipedia:Fadrozole
Wikidata:Q5429279
NCI Thesaurus Code:C79911
Pharos Ligand ID:MSK42XHU1T6H
ChEMBL ID:CHEMBL9298
Mol file:102676-47-1.mol

Synonyms:CGS 020286A;CGS 16949A;CGS-020286A;CGS-16949A;CGS020286A;CGS16949A;FAD 286;FAD-286;FAD286;Fadrozole;Fadrozole Hydrochloride;Fadrozole Monohydrochloride;Hydrochloride, Fadrozole;Monohydrochloride, Fadrozole

Suppliers and Price of Fadrozole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

CSNpharm
Fadrozole
50mg
$ 235.00

Crysdot
Fadrozole 95+%
1g
$ 455.00

Arctom
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile ≥95%
50mg
$ 210.00

Arctom
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile ≥95%
25mg
$ 119.00

Arctom
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile ≥95%
1g
$ 1339.00

Arctom
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile ≥95%
5mg
$ 39.00

American Custom Chemicals Corporation
FADROZOLE 95.00%
5G
$ 1855.51

American Custom Chemicals Corporation
FADROZOLE 95.00%
1G
$ 975.45

Ambeed
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 95+%
10mg
$ 95.00

Ambeed
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile 95+%
5mg
$ 71.00

Total 33 raw suppliers

Chemical Property of Fadrozole

Chemical Property:

Vapor Pressure:1.95E-09mmHg at 25°C
Melting Point:0°C
Boiling Point:0°C
PKA:7.16±0.40(Predicted)
Flash Point:245.1°C
PSA：41.61000
Density:1.2g/cm³
LogP:2.68048
Storage Temp.:2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:223.110947427
Heavy Atom Count:17
Complexity:311

Purity/Quality:

99%, ^*data from raw suppliers

Fadrozole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 20/21/22
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
Recent EU Clinical Trials:DP13 – A Phase II Study in Patients with Primary Aldosteronism to Evaluate the Efficacy, Safety and Tolerability of the Aldosterone Synthase Inhibitor, DP13, over an 8-week Treatment Period
Uses Antineoplastic

Technology Process of Fadrozole

There total 11 articles about Fadrozole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 102676-43-7
5-(4-carbamylphenyl)-5,6,7,8-tetrahydroimidazo<1,5-a>pyridine

: 102676-47-1,102676-86-8,102676-87-9,131833-76-6
fadrozole

Guidance literature:: With trichlorophosphate; In chloroform; for 15h; Heating;
DOI:10.1021/jm00106a038

Reference yield:

: 4385-61-9
ethyl 4-(2-pyridinyl)benzoate

: 102676-47-1,102676-86-8,102676-87-9,131833-76-6
fadrozole

Guidance literature:: Multi-step reaction with 10 steps

1: 40percent peracetic acid / 3 h / 90 °C

2: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

3: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

4: 83 percent / 15 h / 90 °C

5: 73 percent / POCl₃ / toluene / 15 h / 90 °C

6: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

7: 95 percent / 1 N NaOH / ethanol / 3 h / Heating

8: SOCl₂ / 0.5 h / Heating

9: NH₃ (gas) / CH₂Cl₂ / 15 h

10: 85 percent / POCl₃ / CHCl₃ / 15 h / Heating

With hydrogenchloride; peracetic acid; sodium hydroxide; thionyl chloride; ammonia; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm00106a038

Reference yield:

: 102676-38-0
2-<4-(ethoxycarbonyl)phenyl>pyridine N-oxide

: 102676-47-1,102676-86-8,102676-87-9,131833-76-6
fadrozole

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h

2: 65 percent / H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

3: 83 percent / 15 h / 90 °C

4: 73 percent / POCl₃ / toluene / 15 h / 90 °C

5: 85 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr

6: 95 percent / 1 N NaOH / ethanol / 3 h / Heating

7: SOCl₂ / 0.5 h / Heating

8: NH₃ (gas) / CH₂Cl₂ / 15 h

9: 85 percent / POCl₃ / CHCl₃ / 15 h / Heating

With hydrogenchloride; sodium hydroxide; thionyl chloride; ammonia; hydrogen; dimethyl sulfate; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jm00106a038