(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Base Information

Chemical Name:(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol
CAS No.:1253197-41-9
Molecular Formula:C₂₂H₂₇NO₂
Molecular Weight:337.462
Hs Code.:

Synonyms:(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Suppliers and Price of (+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

There total 9 articles about (+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1253197-35-1
(+/-)-cis-7-(benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-41-9
(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 750.075 Torr;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 1253197-41-9
(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h

2: palladium 10% on activated carbon; hydrogen / 2 h / 20 °C / 750.08 Torr

With palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1253197-41-9
(+/-)-cis-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

2.2: 1 h / Cooling with ice

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: methanol; magnesium / 5 h / Reflux

6.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 16 h

7.1: palladium 10% on activated carbon; hydrogen / 2 h / 20 °C / 750.08 Torr

With methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; magnesium; acetic acid; In dichloromethane; 1,2-dichloro-ethane; acetone;