methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

Base Information

Chemical Name:methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate
CAS No.:797049-73-1
Molecular Formula:C₂₀H₃₁FN₂O₅S
Molecular Weight:430.541
Hs Code.:

Synonyms:methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

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Chemical Property of methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

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Technology Process of methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

There total 4 articles about methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 797049-69-5
(R)-2-(4-fluorobenzenesulfonylamino)-4-methylpentanoic acid

: methyl (S)-3-amino-5-methylhexanoate trifluoroacetic acid salt

: 797049-73-1
methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h;
DOI:10.1071/CH04080

Reference yield:

: 797049-67-3
methyl (R)-2-(4-fluorobenzenesulfonylamino)-4-methylpentanoate

: 797049-73-1
methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / KOH / H₂O; tetrahydrofuran / 3 h / 40 °C

2: 78 percent / BOP; iPr₂NEt / CH₂Cl₂ / 24 h

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1071/CH04080

Reference yield:

: (R)-3-Amino-4-methyl-pentanoic acid methyl ester; hydrobromide

: 797049-73-1
methyl (3S,3'R)-3-[3-(4-fluorobenzenesulfonylamino)-4-methylpentanoylamino]-5-methylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / iPr₂NEt / CH₂Cl₂ / 4 h / Heating

2: 94 percent / KOH / H₂O; tetrahydrofuran / 3 h / 40 °C

3: 78 percent / BOP; iPr₂NEt / CH₂Cl₂ / 24 h

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1071/CH04080