4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide

Base Information

• Chemical Name: 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide
• CAS No.: 1103778-38-6
• Molecular Formula: C₃₂H₃₂BN₃O₆
• Molecular Weight: 565.434
• Mol file: 1103778-38-6.mol

Synonyms:4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide

Chemical Property of 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide

There total 2 articles about 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-(2-bromobenzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide (1103778-33-1) → 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide (1103778-38-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; In dimethyl sulfoxide; at 80 - 85 ℃; for 5h; Inert atmosphere;

DOI:10.1039/b921163b

Reference yield: 45.0%

4-(2-bromobenzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide (1103778-33-1) + 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane (201733-56-4) → 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide (1103778-38-6)

Guidance literature:

With PdCl₂(dppf); KOAc; In dimethylsulfoxide;

DOI:10.1039/b921163b

Reference yield: 66.0%

4-(2-dihydroxylboryl-benzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide (1103778-38-6) → 4-(2-dihydroxylboryl-benzyl)amino-N-(4'-aminomethylbenzyl)-1,8-naphthalimide (1103778-34-2)

Guidance literature:

With TFA; In CH₂Cl₂;

DOI:10.1039/b921163b

upstream raw materials:

4-(2-bromobenzyl)amino-N-(4'-Boc-aminomethylbenzyl)-1,8-naphthalimide

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

Downstream raw materials:

4-(2-dihydroxylboryl-benzyl)amino-N-(4'-aminomethylbenzyl)-1,8-naphthalimide