N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine

Base Information

• Chemical Name: N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine
• CAS No.: 1075753-83-1
• Molecular Formula: C₃₈H₃₈N₂O₇
• Molecular Weight: 634.729

Synonyms:N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine

Chemical Property of N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine

Chemical Property:

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Technology Process of N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine

There total 1 articles about N₃-benzoyl-N¹-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N3-benzoyl-N1-(3-hydroxy-2-hydroxymethyl-2-methylpropyl)thymine (1075753-82-0) + 4,4'-dimethoxytrityl chloride (40615-36-9) → N3-benzoyl-N1-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine (1075753-83-1)

Guidance literature:

With pyridine; dmap; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.07.040

Reference yield: 82.0%

N3-benzoyl-N1-(3-(4,4'-dimethoxytrityl)hydroxy-2-hydroxymethyl-2-methylpropyl)thymine (1075753-83-1) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 3-[3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-2-methoxy-(4,4'-dimethoxytrityl)-2-methylpropyl-2-cyanoethyldiisopropylphosphoramidite (1075753-84-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h; Inrert atmosphere;

DOI:10.1016/j.bmc.2008.07.040

upstream raw materials:

N₃-benzoyl-N¹-(3-hydroxy-2-hydroxymethyl-2-methylpropyl)thymine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

3-[3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-2-methoxy-(4,4'-dimethoxytrityl)-2-methylpropyl-2-cyanoethyldiisopropylphosphoramidite

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