(3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

Base Information

Chemical Name:(3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol
CAS No.:1006585-98-3
Molecular Formula:C₂₅H₂₅NO₇S
Molecular Weight:483.542
Hs Code.:

Synonyms:(3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

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Chemical Property of (3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

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Technology Process of (3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

There total 2 articles about (3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 57134-53-9
3,4-methylenedioxyphenylethyne

: 1006585-84-7
C₁₆H₁₉NO₅S

: 1006585-98-3
(3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

Guidance literature:: 3,4-methylenedioxyphenylethyne; With n-butyllithium; In hexane; toluene; for 0.166667h; cooling;

With dimethylaluminum chloride; In hexane; dichloromethane; toluene; cooling;

C₁₆H₁₉NO₅S; In hexane; dichloromethane; toluene; at -20 - 20 ℃; Further stages.;
DOI:10.1021/ol702440f

Reference yield:

: 57134-53-9
3,4-methylenedioxyphenylethyne

: 393165-22-5
C₁₆H₁₉NO₅S

: 1006585-98-3
(3aS,4R,5R,6R,7S,7aR)-6-(1,3-benzodioxol-5-ylethynyl)-2,2-dimethyl-8-[(4-methylphenyl)sulfonyl]hexahydro-4,5-epimino-1,3-benzodioxol-7-ol

Guidance literature:: 3,4-methylenedioxyphenylethyne; With n-butyllithium; In hexane; toluene; at -50 ℃; for 0.333333h; Inert atmosphere;

With dimethylaluminum chloride; In hexane; dichloromethane; toluene; at -50 - 20 ℃; for 1.16667h; Inert atmosphere;

C₁₆H₁₉NO₅S; In hexane; dichloromethane; toluene; at -20 - 20 ℃; for 5.33333h; Inert atmosphere;
DOI:10.1021/jo1003136