(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

Base Information

Chemical Name:(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester
CAS No.:111604-97-8
Molecular Formula:C₂₄H₂₆F₃NO₅
Molecular Weight:465.469
Hs Code.:

Synonyms:(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

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Chemical Property of (2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

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Technology Process of (2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

There total 3 articles about (2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tin(II)chloride dihydrate

: 111604-96-7
α-(2-Propenyl)-[2-(2-nitro-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

: 111604-97-8
(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

Guidance literature:: With hydrogenchloride; potassium carbonate; In methanol; ethyl acetate;

Reference yield:

: 111604-96-7
α-(2-Propenyl)-[2-(2-nitro-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

: 111604-97-8
(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In methanol; for 1.5h; Ambient temperature;
DOI:10.1021/jm00082a019

Reference yield:

: 111604-85-4
[2-(5-trifluoromethyl-2-nitrophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester

: 111604-97-8
(2-Propenyl)-[2-(2-amino-5-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 20 min, 2.) DMF, 4.5 h

2: SnCl₂*2H₂O, concd. HCl / methanol / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydride; tin(ll) chloride; In methanol;
DOI:10.1021/jm00082a019