[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester
CAS No.:197652-25-8
Molecular Formula:C₃₉H₄₃N₅O₅
Molecular Weight:661.801
Hs Code.:

[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

Synonyms:[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

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Chemical Property of [1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

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Technology Process of [1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

There total 9 articles about [1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15030-72-5
Z-Aib-OH

: 197652-25-8
[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Py, benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

3: anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; methoxybenzene; triethylamine; In dichloromethane;
DOI:10.1021/jm970816j

Reference yield:

: 5465-63-4
2-bromobenzylamine hydrochloride

: 197652-25-8
[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Et₃N / 1.) methylene chloride, 0 deg C, 5 min, 2.) methylene chloride, 2 h

2: 100 percent / 5N aq. NaOH, Pd(PPh₃)4 / benzene; propan-2-ol / 2 h / Heating

3: 92 percent / Bu₄NF / tetrahydrofuran / 2 h / Ambient temperature

4: 97 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

5: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

6: anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

7: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium hydride; methoxybenzene; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm970816j

Reference yield:

: 137036-55-6
(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one

: 197652-25-8
[1-((R)-1-{2'-[(3-Ethyl-ureido)-methyl]-biphenyl-4-ylmethyl}-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Py, benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 0 deg C, 15 min

3: anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydride; methoxybenzene; triethylamine; In dichloromethane;
DOI:10.1021/jm970816j