N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide
CAS No.:1421767-16-9
Molecular Formula:C₃₂H₃₀F₃N₃O₇
Molecular Weight:625.601
Hs Code.:

N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Synonyms:N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Suppliers and Price of N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

There total 5 articles about N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421767-13-6
C₃₀H₂₈N₂O₇

: 1421767-16-9
N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / -78 - 20 °C

2.1: pyridine / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 20 - 100 °C

4.1: triphenylphosphine / 1,4-dioxane; water / 4 h / 55 °C

4.2: 1 h / 20 °C

5.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; sodium azide; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.12.028

Reference yield:

: 1421767-14-7
((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate

: 1421767-16-9
N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 - 100 °C

2.1: triphenylphosphine / 1,4-dioxane; water / 4 h / 55 °C

2.2: 1 h / 20 °C

3.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; sodium azide; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.12.028

Reference yield:

: 1-{(2R,3R,4S,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-vinyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

: 1421767-16-9
N-(((2R,3R,4S,5R)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(((4-methoxyphenyl)diphenylmethoxy)methyl)-tetrahydrofuran-3-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: osmium(VIII) oxide; sodium periodate; 2,6-dimethylpyridine / 1,4-dioxane; water / 3 h / 20 °C

2.1: sodium tetrahydroborate / methanol / -78 - 20 °C

3.1: pyridine / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 20 - 100 °C

5.1: triphenylphosphine / 1,4-dioxane; water / 4 h / 55 °C

5.2: 1 h / 20 °C

6.1: pyridine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; triphenylphosphine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.12.028