N-(4-Methoxyphenyl)-N-phenylacetamide

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-N-phenylacetamide
• CAS No.: 32047-93-1
• Molecular Formula: C15H15 N O2
• Molecular Weight: 241.29
• Hs Code.: 2924299090
• NSC Number: 135977
• UNII: RFS2JR213G
• DSSTox Substance ID: DTXSID60953922
• Nikkaji Number: J30.966D
• Mol file: 32047-93-1.mol

Synonyms:N-(4-Methoxyphenyl)-N-phenylacetamide;p-Acetanisidide, N-phenyl-;32047-93-1;N,N-(4-Methoxy)diphenylacetamide;N-(p-Methoxyphenyl)-N-phenylacetamide;ACETAMIDE, N-(p-METHOXYPHENYL)-N-PHENYL-;NSC 135977;BRN 2974893;RFS2JR213G;NSC-135977;NSC135977;UNII-RFS2JR213G;N-(4-Methoxyphenyl)acetanilide;DTXSID60953922;LIGPOLGDSMDKPB-UHFFFAOYSA-N;ADAL1072887;LS-9853;N-(4-Methoxyphenyl)-N-phenylacetamide #;Acetamide, N-(4-methoxyphenyl)-N-phenyl-

Chemical Property of N-(4-Methoxyphenyl)-N-phenylacetamide

Chemical Property:

• Vapor Pressure: 8.03E-09mmHg at 25°C
• Melting Point: 109-110 °C
• Boiling Point: 464.9°Cat760mmHg
• PKA: -2.48±0.50(Predicted)
• Flash Point: 235°C
• PSA: 29.54000
• Density: 1.14g/cm³
• LogP: 3.37980
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

97% ^*data from raw suppliers

N-(4-METHOXYPHENYL)-N-PHENYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C1=CC=CC=C1)C2=CC=C(C=C2)OC

Technology Process of N-(4-Methoxyphenyl)-N-phenylacetamide

There total 13 articles about N-(4-Methoxyphenyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

para-iodoanisole (696-62-8) + Acetanilid (103-84-4) → N-(4-methoxyphenyl)-N-phenylacetamide (32047-93-1)

Guidance literature:

With aluminum oxide; potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; In toluene; at 110 ℃; for 8h;

DOI:10.1055/s-2004-829099

Reference yield: 91.0%

iodobenzene (591-50-4) + 4-methoxyacetanilide (51-66-1) → N-(4-methoxyphenyl)-N-phenylacetamide (32047-93-1)

Guidance literature:

With potassium phosphate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; In toluene; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol200750p

Reference yield: 85.0%

Diphenyliodonium triflate (66003-76-7) + 4-methoxyacetanilide (51-66-1) → N-(4-methoxyphenyl)-N-phenylacetamide (32047-93-1)

Guidance literature:

With sodium hydride; In toluene; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01079

upstream raw materials:

1-bromo-4-methoxy-benzene

Acetanilid

4-methoxyphenylboronic acid

(E)-N-(1-(4-methoxyphenyl)ethylidene)aniline

Downstream raw materials:

N-(4-methoxyphenyl)phenylamine