(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

Base Information

Chemical Name:(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt
CAS No.:108165-87-3
Molecular Formula:C₂₀H₁₃BrNO₃*Na
Molecular Weight:418.222
Hs Code.:

Synonyms:(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

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Chemical Property of (D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

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Technology Process of (D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

There total 7 articles about (D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108177-35-1
methyl D,L-2-<3-<2-(7-bromo-2-quinolinyl)ethynyl>phenoxy>propanoate

: 108165-87-3
(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

Guidance literature:: With sodium hydroxide; In ethanol; Ambient temperature;
DOI:10.1021/jm00099a011

Reference yield:

: 4965-34-8
2-methyl-7-bromo-quinoline

: 108165-87-3
(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / acetic anhydride / 48 h / 130 °C

2: 1.) Br₂, 2.) acetic anhydride, 3.) DBU

3: 100 percent / potassium carbonate / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

4: 97 percent / butan-2-one / Heating

5: 96 percent / 10 N aq. NaOH / ethanol / Ambient temperature

With sodium hydroxide; bromine; acetic anhydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; ethanol; acetic anhydride; butanone;
DOI:10.1021/jm00099a011

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 108165-87-3
(D,L) 2-(3-(2-(7-bromoquinolin-2-yl)ethynyl)phenoxy)propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / acetic anhydride / 48 h / 130 °C

2: 1.) Br₂, 2.) acetic anhydride, 3.) DBU

3: 100 percent / potassium carbonate / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

4: 97 percent / butan-2-one / Heating

5: 96 percent / 10 N aq. NaOH / ethanol / Ambient temperature

With sodium hydroxide; bromine; acetic anhydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; ethanol; acetic anhydride; butanone;
DOI:10.1021/jm00099a011