2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester
• CAS No.: 222639-66-9
• Molecular Formula: C₂₉H₃₅NO₆
• Molecular Weight: 493.6
• Mol file: 222639-66-9.mol

Synonyms:2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property of 2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester

There total 1 articles about 2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

9-Fluorenylmethanol (24324-17-2) + Boc-Asp(O-cyclohexyl)-OH (73821-95-1) → 2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester (222639-66-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 30h; Ambient temperature;

DOI:10.1021/jo982125g

Reference yield: 91.0%

2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester (222639-66-9) → 1-α-(9-fluorenylmethyl)-β-cyclohexyl-aspartate hydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; Ambient temperature;

DOI:10.1021/jo982125g

Reference yield:

2-tert-butoxycarbonylamino-succinic acid 4-cyclohexyl ester 1-(9H-fluoren-9-ylmethyl) ester (222639-66-9) → tert-butyl 2(S)-<(9-fluorenylmethoxycarbonyl)amino>-4-<1(S)-(9-fluorenylmethoxycarbonyl)-2-(cyclohexyloxycarbonyl)ethylamino>butyrate

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / HCl / ethyl acetate / Ambient temperature

2: 92 percent / NaBH(OAc)3 / dimethylformamide / 0.5 h / Ambient temperature

With hydrogenchloride; sodium tris(acetoxy)borohydride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jo982125g

upstream raw materials:

9-Fluorenylmethanol

Boc-Asp(O-cyclohexyl)-OH