7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

Base Information

Chemical Name:7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III
CAS No.:925211-34-3
Molecular Formula:C₄₉H₈₄O₁₀Si₄
Molecular Weight:948.518
Hs Code.:

Synonyms:7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

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Technology Process of 7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

There total 1 articles about 7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 19259-90-6
[2H₃]acetyl chloride

: 1-dimethylsilyl-7,10,13-tris(triethylsilyl)-4,10-deacetyl-4-hydroxybaccatin III

: 925211-34-3
7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1021/ja0656604

Reference yield:

: 925211-34-3
7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

: 925211-35-4
4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin III

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja0656604

Reference yield:

: 925211-34-3
7,10,13-tri-(triethylsilyl)-1-dimethylsilyl-4,10-dideacetyl-4-(d3-acetyl)-baccatin III

: 925211-38-7
2'-O-(triisopropyl)-3'-(p-fluorophenyl)-7-O-triethylsilyl-4-deacetyl-4-(d3-acetyl)-paclitaxel

Guidance literature:: Multi-step reaction with 4 steps

1.1: HF*pyridine / tetrahydrofuran / 20 °C

2.1: CeCl₃ / tetrahydrofuran / 0.33 h / 20 °C

2.2: 147 mg / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / imidazole / dimethylformamide / 0.5 h / 20 °C

4.1: 73 percent / LHMDS / tetrahydrofuran / 4 h / -45 °C

With 1H-imidazole; cerium(III) chloride; pyridine hydrogenfluoride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0656604