2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

Base Information

Chemical Name:2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone
CAS No.:1312886-48-8
Molecular Formula:C₂₂H₁₆ClF₃N₂O
Molecular Weight:416.83
Hs Code.:

Synonyms:2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

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Chemical Property of 2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

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Technology Process of 2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

There total 4 articles about 2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1312886-47-7
5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde

: 120-92-3
cyclopentanone

: 1312886-48-8
2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2011.04.027

Reference yield:

: 99-91-2
para-chloroacetophenone

: 1312886-48-8
2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

Guidance literature:: Multi-step reaction with 4 steps

2.1: sulfuric acid / ethanol

3.1: trichlorophosphate / 9 h / 90 °C

3.2: 0 °C

4.1: sodium hydroxide / ethanol; water / 6 h / 20 °C

With sulfuric acid; sodium hydroxide; trichlorophosphate; In ethanol; water; 1.1: Claisen-Schmidt condensation / 3.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.04.027

Reference yield:

: 586333-28-0
5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

: 1312886-48-8
2-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)cyclopentanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 9 h / 90 °C

1.2: 0 °C

2.1: sodium hydroxide / ethanol; water / 6 h / 20 °C

With sodium hydroxide; trichlorophosphate; In ethanol; water; 1.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.04.027