N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide
CAS No.:1464153-66-9
Molecular Formula:C₂₈H₂₃F₃N₆O₃
Molecular Weight:548.524
Hs Code.:

Synonyms:N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

There total 7 articles about N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1464153-62-5
4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoic acid

: 1464153-65-8
2,2,2-trifluoro-N-((4-hydroxypiperidin-4-yl)methyl)acetamide

: 1464153-66-9
N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 1245644-42-1
6-bromo-3-iodo-imidazo[1,2-a]pyrazine

: 1464153-66-9
N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; N,N-dimethyl-formamide / 1 h / 90 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 12 h / 20 °C

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 10 h / 20 °C

With 4-methyl-morpholine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1464153-49-8
4-(6-bromoimidazo[1,2-a]pyrazin-3-vl)benzonitrile

: 1464153-66-9
N-((1-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyrazin-6-yl)benzoyl)-4-hydroxypiperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

2: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 12 h / 20 °C

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 10 h / 20 °C

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;