3-Morpholinorifamycin SV

Base Information

• Chemical Name: 3-Morpholinorifamycin SV
• CAS No.: 16286-09-2
• Molecular Formula: C₄₁H₅₄N₂O₁₃
• Molecular Weight: 782.885
• Mol file: 16286-09-2.mol

Synonyms:3-Morpholinorifamycin SV;Ciba 41137;Ba 41137;Rifamycin, 3-(4-morpholinyl)-;16286-09-2;2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 2,4,12,16,18,20,22-heptamethyl-5,6,9,17,19,21-hexahydroxy-23-methoxy-8-morpholino-, 21-acetate;C41H54N2O13;LS-64214

Chemical Property of 3-Morpholinorifamycin SV

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 978.6°Cat760mmHg
• Flash Point: 545.6°C
• Density: 1.37g/cm³
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 4
• Exact Mass: 782.36258978
• Heavy Atom Count: 56
• Complexity: 1500

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C(=C2N5CCOCC5)O)O)C
• Isomeric SMILES: CC1/C=C/C=C(/C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(O/C=C/C(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C(=C2N5CCOCC5)O)O)\C

Technology Process of 3-Morpholinorifamycin SV

There total 3 articles about 3-Morpholinorifamycin SV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-morpholin-4-yl-O1,O4-didehydro-rifamycin (19306-05-9) → 3-morpholin-4-yl-rifamycin (16286-09-2)

Guidance literature:

With ascorbic acid; In methanol; chloroform; water;

DOI:10.1002/hlca.19730560720

Reference yield:

rifamycin S (62623-68-1,76188-88-0,81203-58-9,101978-28-3,13553-79-2) → 3-morpholin-4-yl-rifamycin (16286-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) dioxane, (ii) K₃, aq. NaHCO₃, CHCl₃, MeOH

2: ascorbic acid / methanol; H₂O; CHCl₃

With ascorbic acid; In methanol; chloroform; water;

DOI:10.1002/hlca.19730560720

Reference yield:

→ 3-Morpholinorifamycin SV (16286-09-2)

Guidance literature:

3-Morpholinorifamycin S(Ia),Ascorbinsaeure;

upstream raw materials:

3-morpholin-4-yl-O¹,O⁴-didehydro-rifamycin

rifamycin S

Refernces