Ritolukast

Base Information

Chemical Name:Ritolukast
CAS No.:111974-60-8
Molecular Formula:C17H13 F3 N2 O3 S
Molecular Weight:382.363
Hs Code.:

Synonyms:Ritolukast;Wy 48252

Suppliers and Price of Ritolukast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Ritolukast

Chemical Property:

Vapor Pressure:4.65E-09mmHg at 25°C
Boiling Point:471.4°Cat760mmHg
Flash Point:238.9°C
Density:1.479g/cm³

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ritolukast

There total 5 articles about Ritolukast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 105326-65-6
3-[(2-quinolinyl)methoxy]benzenamine

: 111974-60-8
1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; for 2h; -70 deg C to 10 deg C;
DOI:10.1021/jm00126a006

Reference yield: 28.0%

: 4377-41-7
2-Chloromethylquinoline

: 358-23-6
trifluoromethylsulfonic anhydride

: 105326-65-6
3-[(2-quinolinyl)methoxy]benzenamine

: 111974-60-8
1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]methanesulfonamide

Guidance literature:: In dichloromethane;

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 111974-60-8
1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Cs₂CO₃, KI / acetone / 18 h / Heating

2: 80 percent / H₂ / PtO₂ / ethanol / 0.5 h / 1810.02 Torr

3: 33 percent / Et₃N / CH₂Cl₂ / 2 h / -70 deg C to 10 deg C

With hydrogen; caesium carbonate; triethylamine; potassium iodide; platinum(IV) oxide; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm00126a006