4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

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Chemical Name:4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine
CAS No.:188559-32-2
Molecular Formula:C₃₈H₃₅ClN₂O₅
Molecular Weight:635.159
Hs Code.:

Synonyms:4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

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Chemical Property of 4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

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Technology Process of 4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

There total 7 articles about 4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 4-Allyloxy-2,5-dichloro-pyrimidine

: (2R,3R)-5-Benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-ol

: 188559-32-2
4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(96)02520-8

Reference yield:

: 134485-31-7
5,5-Dibenzyloxy-2E-penten-1-ol

: 188559-32-2
4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, DMAP

2: K₂OsO₄*2H₂O, K₃Fe(CN)6, K₂CO₃, DHQD-PHN / H₂O; 2-methyl-propan-2-ol

3: H₂SO₄ / tetrahydrofuran / 0 °C

4: 67 percent / NaH / dimethylformamide

With dmap; potassium osmate(VI); sulfuric acid; sodium hydride; potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(96)02520-8

Reference yield:

: 134485-30-6
ethyl-3,3-di(benzyl)oxypropanoate

: 188559-32-2
4-Allyloxy-2-((2R,3R)-5-benzyloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy)-5-chloro-pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: DIBAL-H / diethyl ether / -78 °C

2: NaH / tetrahydrofuran

3: DIBAL-H / diethyl ether / -78 °C

4: Et₃N, DMAP

5: K₂OsO₄*2H₂O, K₃Fe(CN)6, K₂CO₃, DHQD-PHN / H₂O; 2-methyl-propan-2-ol

6: H₂SO₄ / tetrahydrofuran / 0 °C

7: 67 percent / NaH / dimethylformamide

With dmap; potassium osmate(VI); sulfuric acid; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 9-O-(9'-phenanthryl) ether of dihydroquinidine; triethylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(96)02520-8