(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

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Chemical Name:(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile
CAS No.:553635-34-0
Molecular Formula:C₂₈H₂₇ClN₆O₃
Molecular Weight:531.014
Hs Code.:

Synonyms:(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

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Chemical Property of (S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

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Technology Process of (S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

There total 5 articles about (S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 553635-33-9
(S)-1-[7-benzenesulfonyl-4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]-4-(2-chlorophenyl)piperidine-4-carbonitrile

: 553635-34-0
(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

Guidance literature:: With sodium hydroxide; water; In methanol; at 20 ℃; for 2h;

Reference yield:

: 186347-31-9
4-(2-chlorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester

: 553635-34-0
(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1.5 h

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / DMF (N,N-dimethyl-formamide) / 6 h / 20 °C

3: sodium hydroxide; water / methanol / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; In 1,4-dioxane; methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: C₁₂H₈ClN₃*ClH

: 553635-34-0
(S)-4-(2-chlorophenyl)-1-[4-(2,3-dihydroxypropylamino)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl]piperidine-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.33 h / 0 °C

1.2: 4 h

2.1: LDA-THF / tetrahydrofuran; cyclohexane / 0.75 h / -78 °C / Cooling with acetone-dry ice

2.2: 0.08 h / -78 °C

3.1: dimethyl sulfoxide / 4 h / 80 °C

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / DMF (N,N-dimethyl-formamide) / 6 h / 20 °C

5.1: sodium hydroxide; water / methanol / 2 h / 20 °C

With sodium hydroxide; LDA-THF; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydride; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); cyclohexane; dimethyl sulfoxide; N,N-dimethyl-formamide; oil;