ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Base Information

Chemical Name:ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate
CAS No.:1359983-14-4
Molecular Formula:C₁₈H₁₄ClF₂NO₂S
Molecular Weight:381.83
Hs Code.:

Synonyms:ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Suppliers and Price of ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

There total 6 articles about ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1359983-13-3
ethyl 2-fluoro-3-mercaptobenzoate

: 6-chloro-7-fluoro-2-methyl-1H-indole

: 1359983-14-4
ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Guidance literature:: ethyl 2-fluoro-3-mercaptobenzoate; With N-chloro-succinimide; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

6-chloro-7-fluoro-2-methyl-1H-indole; In dichloromethane; for 12h;

Reference yield:

: 2106-49-2
1-chloro-2-fluoro-3-nitrobenzene

: 1359983-14-4
ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2.1: N-chloro-succinimide / dichloromethane / Inert atmosphere

2.2: 12 h

With N-chloro-succinimide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 334792-76-6
ethyl 3-bromo-2-fluorobenzoate

: 1359983-14-4
ethyl 3-((6-chloro-7-fluoro-2-methyl-1H-indol-3-yl)thio)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / 12 h / 80 °C / Inert atmosphere

3.1: N-chloro-succinimide / dichloromethane / Inert atmosphere

3.2: 12 h

With N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; trifluoroacetic acid;