2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine
CAS No.:855959-64-7
Molecular Formula:C₂₈H₂₅N₃O
Molecular Weight:419.526
Hs Code.:

Synonyms:2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

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Chemical Property of 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

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Technology Process of 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

There total 7 articles about 2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 855959-45-4
(2R)-N-(3-aminopyridin-4-yl)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanamide

: 855959-64-7
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

Guidance literature:: With acetic acid; at 65 ℃; for 2.5h;
DOI:10.1002/hlca.200590051

Reference yield:

: 855959-36-3
(2R)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanoic acid

: 855959-64-7
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

1.2: 57 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

2.1: 100 percent / AcOH / 2.5 h / 65 °C

With oxalyl dichloride; acetic acid; In dichloromethane;
DOI:10.1002/hlca.200590051

Reference yield:

: 855959-31-8
(4S)-4-benzyl-3-[(2R)-3-(benzyloxy)-2-([1,1'-biphenyl-4-yl]methyl)propanoyl]-1,3-oxazolidin-2-one

: 855959-64-7
2-[(1S)-2-(benzyloxy)-1-([1,1'-biphenyl-4-yl]methyl)ethyl]-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 73 percent / H₂O₂; LiOH*H₂O / tetrahydrofuran; H₂O / 2.5 h / 20 °C

2.1: (COCl)2 / CH₂Cl₂ / 12 h / 20 °C

2.2: 57 percent / NEt₃ / tetrahydrofuran / 12 h / 20 °C

3.1: 100 percent / AcOH / 2.5 h / 65 °C

With lithium hydroxide; oxalyl dichloride; dihydrogen peroxide; acetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/hlca.200590051