1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine

Base Information

• Chemical Name: 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine
• CAS No.: 865758-88-9
• Molecular Formula: C₃₈H₄₁NO₅
• Molecular Weight: 591.747
• Mol file: 865758-88-9.mol

Synonyms:1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine

Chemical Property of 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine

There total 2 articles about 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetyl-2-(1-benzyloxyallyl)-3-hydroxy-4,5-epoxypiperidine (865758-86-7) → 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine (865758-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 55 percent / aq. sodium benzoate / 12 h / 130 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: 94 percent / dimethylformamide / 2 h

With sodium benzoate; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.07.014

Reference yield:

1-[(2S,3S)-2-((S)-1-Benzyloxy-allyl)-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-ethanone (791821-67-5) → 1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine (865758-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 50 percent / vanadyl acetylacetonate; tBuOOH / CH₂Cl₂; decane / 5 h / 25 °C

2.1: 55 percent / aq. sodium benzoate / 12 h / 130 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 94 percent / dimethylformamide / 2 h

With tert.-butylhydroperoxide; sodium benzoate; vanadyl acetylacetonate; sodium hydride; In decane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.07.014

Reference yield: 78.0%

1-acetyl-2-(1-benzyloxyallyl)-3,4,5-tribenzyloxypiperidine (865758-88-9) → 2-(1-benzyloxy-2,3-dihydroxypropyl)-3,4,5-tribenzyloxypiperidine + 2-(1-benzyloxy-2,3-dihydroxypropyl)-3,4,5-tribenzyloxypiperidine (865758-90-3)

Guidance literature:

With osmium(VIII) oxide; N-methyl-2-indolinone; In water; acetone; at 25 ℃; for 4h;

DOI:10.1016/j.tet.2005.07.014

upstream raw materials:

1-acetyl-2-(1-benzyloxyallyl)-3-hydroxy-4,5-epoxypiperidine

1-[(2S,3S)-2-((S)-1-Benzyloxy-allyl)-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Downstream raw materials:

2-(1-benzyloxy-3-hydroxypropyl)-3,4,5-tribenzyloxypiperidine

2-(1-benzyloxy-2,3-dihydroxypropyl)-3,4,5-tribenzyloxypiperidine

1,6,7,8-tetrabenzyloxy-2-hydroxyindolizidine

1,6,7,8-tetrabenzyloxy-2-hydroxyindolizidine