2′,4′-dihydroxy-4,6′-dimethoxychalcone

Base Information

• Chemical Name: 2′,4′-dihydroxy-4,6′-dimethoxychalcone
• CAS No.: 855740-21-5
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.311
• Mol file: 855740-21-5.mol

Synonyms:2′,4′-dihydroxy-4,6′-dimethoxychalcone

Chemical Property of 2′,4′-dihydroxy-4,6′-dimethoxychalcone

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2′,4′-dihydroxy-4,6′-dimethoxychalcone

There total 3 articles about 2′,4′-dihydroxy-4,6′-dimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4,6-dihydroxy-2-methoxyacetophenone (3602-54-8) + 4-methoxy-N-methylbenzylamine (702-24-9) → 2′,4′-dihydroxy-4,6′-dimethoxychalcone (855740-21-5)

Guidance literature:

With ammonium peroxydisulfate; In tert-Amyl alcohol; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;

DOI:10.1039/c3gc41403e

Reference yield:

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) → 2′,4′-dihydroxy-4,6′-dimethoxychalcone (855740-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / chlorobenzene / 1 h / Reflux; Sealed tube; Schlenk technique

2: ammonium peroxydisulfate / tert-Amyl alcohol / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry

With aluminum (III) chloride; ammonium peroxydisulfate; In tert-Amyl alcohol; chlorobenzene;

DOI:10.1039/c3gc41403e

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 2′,4′-dihydroxy-4,6′-dimethoxychalcone (855740-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 6 h / 65 °C / Schlenk technique; Sealed tube

2: aluminum (III) chloride / chlorobenzene / 1 h / Reflux; Sealed tube; Schlenk technique

3: ammonium peroxydisulfate / tert-Amyl alcohol / 24 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry

With aluminum (III) chloride; ammonium peroxydisulfate; potassium carbonate; In tert-Amyl alcohol; chlorobenzene; acetone;

DOI:10.1039/c3gc41403e

upstream raw materials:

4,6-dihydroxy-2-methoxyacetophenone

4-methoxy-N-methylbenzylamine

2-hydroxy-4,6-dimethoxyacetophenone

2,4,6-trihydroxyacetophenone

Downstream raw materials:

2’,4’-dihydroxy-4,6’-dimethoxydihydrochalcone

Refernces