(7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

Base Information

Chemical Name:(7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione
CAS No.:433289-30-6
Molecular Formula:C₁₉H₁₅BrCl₂N₂O₃
Molecular Weight:470.15
Hs Code.:

Synonyms:(7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

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Chemical Property of (7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

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Technology Process of (7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

There total 2 articles about (7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34893-92-0
3,4-dichlorophenyl isocyanate

: 848475-25-2
(2R,4R)-4-(4-Bromo-benzyloxy)-pyrrolidine-2-carboxylic acid methyl ester

: 433289-30-6
(7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

Guidance literature:: With potassium carbonate; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2004.12.007

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 433289-30-6
(7AR,6R)-2-(3,5-dichloro-phenyl)-6-(4-bromobenzyloxy)-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / dimethylsulfoxide / 3 h / 20 °C

2: TFA / CH₂Cl₂ / 2 h / 20 °C

3: K₂CO₃; triethylamine / CH₂Cl₂ / 24 h / 20 °C

With potassium hydroxide; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.12.007