Technology Process of (5R,8S,E)-8-(bromomethyl)-3-(bromomethylene)-8-phenyl-2,7-dioxaspiro[4.4]nonan-1-one
There total 3 articles about (5R,8S,E)-8-(bromomethyl)-3-(bromomethylene)-8-phenyl-2,7-dioxaspiro[4.4]nonan-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; sodium hydrogencarbonate;
In
dichloromethane;
at -50 ℃;
for 12h;
enantioselective reaction;
Darkness;
DOI:10.1002/anie.201310136
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridinium chlorochromate / dichloromethane / Molecular sieve
2: sodium dihydrogenphosphate; sodium chlorite / tert-butyl alcohol; water / 2 h
3: N-Bromosuccinimide; sodium hydrogencarbonate / dichloromethane / 12 h / -50 °C / Darkness
With
sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; sodium hydrogencarbonate; pyridinium chlorochromate;
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201310136
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium dihydrogenphosphate; sodium chlorite / tert-butyl alcohol; water / 2 h
2: N-Bromosuccinimide; sodium hydrogencarbonate / dichloromethane / 12 h / -50 °C / Darkness
With
sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; sodium hydrogencarbonate;
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/anie.201310136
