N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

Base Information

Chemical Name:N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester
CAS No.:79663-89-1
Molecular Formula:C₃₀H₄₆N₄O₈
Molecular Weight:590.717
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

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Chemical Property of N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

Chemical Property:

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Technology Process of N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

There total 8 articles about N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2577-48-2
L-proline methyl ester

: 79663-89-1
N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 20 h / Ambient temperature

2: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

3: Et₃N / acetonitrile / 0.25 h / -5 °C

4: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

5: H₂ / 10percent Pd/C / ethyl acetate

6: 10.7 g / Et₃N / acetonitrile / -5 deg C, 1 h, RT, 16 h

With sodium hydroxide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; chloroform; ethyl acetate; acetonitrile;
DOI:10.1021/ja00365a032

Reference yield:

: 1685-33-2
carbobenzoxy-D-valine

: 79663-89-1
N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 20 h / Ambient temperature

2: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

3: Et₃N / acetonitrile / 0.25 h / -5 °C

4: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

5: H₂ / 10percent Pd/C / ethyl acetate

6: 10.7 g / Et₃N / acetonitrile / -5 deg C, 1 h, RT, 16 h

With sodium hydroxide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; chloroform; ethyl acetate; acetonitrile;
DOI:10.1021/ja00365a032

Reference yield:

: 51782-77-5
carbobenzoxy-D-valyl-L-proline methyl ester

: 79663-89-1
N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

2: Et₃N / acetonitrile / 0.25 h / -5 °C

3: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

4: H₂ / 10percent Pd/C / ethyl acetate

5: 10.7 g / Et₃N / acetonitrile / -5 deg C, 1 h, RT, 16 h

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/ja00365a032