Fumaramidine

Base Information

• Chemical Name: Fumaramidine
• CAS No.: 76202-52-3
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.443
• Mol file: 76202-52-3.mol

Synonyms:

Chemical Property of Fumaramidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fumaramidine

There total 9 articles about Fumaramidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-{1-[2-(2-dimethylaminoethyl)-4,5-dimethoxyphenyl]meth-(E)-ylidene}-7-(4-methoxybenzyl)-6,7-dihydro[1,3]dioxolo[4,5-e]isoindol-8-one (882503-47-1) → fumaramidine (76202-52-3)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; for 24h; Heating;

DOI:10.1016/j.tet.2006.01.008

Reference yield:

N,N-dimethyl-3,4-dimethoxy-5-bromo-β-phenethylamine (882503-45-9) → fumaramidine (76202-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 70 percent / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 91 percent / anisole; trifluoroacetic acid / 24 h / Heating

With n-butyllithium; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; hexane;

DOI:10.1016/j.tet.2006.01.008

Reference yield:

N-[(4-bromobenzo[1,3]dioxol-5-yl)methylidene]-N-(4-methoxybenzyl)amine (882503-48-2) → fumaramidine (76202-52-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / sodium borohydride / methanol / 0.5 h / 20 °C

2: 73 percent / NaOH / diethyl ether; H₂O / 0.5 h / 0 °C

3: 63 percent / n-BuLi / hexane; tetrahydrofuran / 0.83 h / -90 - -40 °C

4: 91 percent / anisole; trifluoroacetic acid / 24 h / Heating

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; hexane; water; 3: Parham cyclization;

DOI:10.1016/j.tet.2006.01.008

upstream raw materials:

6-{1-[2-(2-dimethylaminoethyl)-4,5-dimethoxyphenyl]meth-(E)-ylidene}-7-(4-methoxybenzyl)-6,7-dihydro[1,3]dioxolo[4,5-e]isoindol-8-one

N,N-dimethyl-3,4-dimethoxy-5-bromo-β-phenethylamine

N-[(4-bromobenzo[1,3]dioxol-5-yl)methylidene]-N-(4-methoxybenzyl)amine

N-(4-bromobenzo[1,3]dioxol-5-ylmethyl)-N-(4-methoxybenzyl)amine