7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Base Information

Chemical Name:7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one
CAS No.:1383531-60-9
Molecular Formula:C₂₀H₁₅FN₂O₃S
Molecular Weight:382.415
Hs Code.:

Synonyms:7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

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Chemical Property of 7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

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Technology Process of 7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

There total 2 articles about 7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383531-57-4
7-bromo-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1383531-60-9
7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In methanol; water; toluene; at 100 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.080

Reference yield:

: 215928-68-0
6-(4-fluorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one

: 1383531-60-9
7-(3,4-dimethoxy-phenyl)-6-(4-fluoro-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; acetic acid / 6 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / methanol; water; toluene / 6 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; sodium carbonate; acetic acid; In methanol; water; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.04.080