5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Base Information

Chemical Name:5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester
CAS No.:685899-14-3
Molecular Formula:C₂₂H₃₀N₄O₅
Molecular Weight:430.504
Hs Code.:

Synonyms:5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

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Chemical Property of 5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

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Technology Process of 5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

There total 11 articles about 5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 685544-38-1
5-[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid ethyl ester

: 685899-14-3
5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; at 20 ℃;
DOI:10.1021/jm030354b

Reference yield:

: 5205-39-0
ethyl glutaroyl chloride

: 685899-14-3
5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

2: hydroxylamine hydrochloride; Et₃N / ethanol / 20 °C

With hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030354b

Reference yield:

: 34702-66-4
8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

: 685899-14-3
5-{2-[4-(N-hydroxycarbamimidoyl)phenyl]-1-oxo-2,8-diazaspiro[4.5]dec-8-yl}-5-oxopentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 92 percent / DIEA / dimethylformamide / 4 h / 20 °C

6.1: hydroxylamine hydrochloride; Et₃N / ethanol / 20 °C

With sodium tetrahydroborate; 10% Cd/Pd; hydroxylamine hydrochloride; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030354b