2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-

Base Information

Chemical Name:2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-
CAS No.:93592-75-7
Molecular Formula:C₂₁H₂₁ClFN₃O
Molecular Weight:385.869
Hs Code.:
ChEMBL ID:CHEMBL350534
DSSTox Substance ID:DTXSID70918300

Synonyms:93592-75-7;2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-;CHEMBL350534;SCHEMBL10619907;DTXSID70918300;7-Chloro-5-(2-fluorophenyl)-1-(1-methylpiperidin-4-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Suppliers and Price of 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:385.1357182
Heavy Atom Count:27
Complexity:578

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(CC1)N2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4F

Technology Process of 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-

There total 5 articles about 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-[[[2-(1-methyl-4-piperidinyl)amino-4-chlorophenyl](2-fluorophenyl)methylen]amino]acetate

: 93592-75-7
7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydroxide; sulfuric acid; In water;

Reference yield:

: 93592-85-9
N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-piperidin-4-yl)-acetamide

: 93592-75-7
7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Yield given; Heating;
DOI:10.1021/jm00383a003

Reference yield:

: 96110-80-4
{4-Chloro-2-[(2-fluoro-phenyl)-imino-methyl]-phenyl}-(1-methyl-piperidin-4-yl)-amine

: 93592-75-7
7-chloro-5-(2-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH / ethanol / 3 h / Heating

2: TFA / 20 h / Heating

With acetic acid; trifluoroacetic acid; In ethanol;
DOI:10.1021/jm00383a003