(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

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Chemical Name:(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone
CAS No.:87692-35-1
Molecular Formula:C₂₉H₄₆O₃Si
Molecular Weight:470.768
Hs Code.:

Synonyms:(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

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Chemical Property of (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

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Technology Process of (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

There total 8 articles about (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 87692-33-9
(1S,2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol

: 87692-35-1
(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane; for 5.5h;

Reference yield:

: 13345-50-1
prostaglandin A₂

: 87692-35-1
(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 0.5 h / 0 - 5 °C

2: imidazole / dimethylformamide / 2 h / Ambient temperature

3: 62 percent / 1 M K-Selectride / tetrahydrofuran / 3 h / -55 - -45 °C

4: 65 percent / N-methylmorpholine N-oxide dihydrate, water, osmium tetraoxide / 2-methyl-propan-2-ol; acetone / 0.67 h / 0 - 5 °C

5: 93 percent / sodium metaperiodate / H₂O; dioxane / Ambient temperature

6: sodium methylsulphinylmethanide / 1.) DMSO, 20 deg C, 30 min, 2.) room temperature, 27 h

7: 44 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 5.5 h

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; water; sodium acetate; sodium methylsulfinylmethanide; potassium tri-sec-butyl-borohydride; 4-methylmorpholine N-oxide; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

Reference yield:

: 31753-19-2
(5Z,13E)-15-hydroxy-9-oxoprosta 5,10,13 trien-1-oic acid

: 87692-35-1
(2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 2 h / Ambient temperature

2: 62 percent / 1 M K-Selectride / tetrahydrofuran / 3 h / -55 - -45 °C

3: 65 percent / N-methylmorpholine N-oxide dihydrate, water, osmium tetraoxide / 2-methyl-propan-2-ol; acetone / 0.67 h / 0 - 5 °C

4: 93 percent / sodium metaperiodate / H₂O; dioxane / Ambient temperature

5: sodium methylsulphinylmethanide / 1.) DMSO, 20 deg C, 30 min, 2.) room temperature, 27 h

6: 44 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 5.5 h

With 1H-imidazole; sodium periodate; osmium(VIII) oxide; water; sodium acetate; sodium methylsulfinylmethanide; potassium tri-sec-butyl-borohydride; 4-methylmorpholine N-oxide; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;