19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

Base Information

Chemical Name:19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione
CAS No.:1165793-60-1
Molecular Formula:C₂₉H₃₆N₄O₄S
Molecular Weight:536.695
Hs Code.:

Synonyms:19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

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Chemical Property of 19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

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Technology Process of 19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

There total 8 articles about 19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19-(4-chlorophenyl)-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-7,14(21),15,17(20),18-pentaene-3,13-dione

: 1165793-60-1
19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

: 1165793-61-2
19-(4-chlorophenyl)-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;

Reference yield:

: C₂₉H₃₃ClN₄O₄S

: 1165793-60-1
19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

: 1165793-61-2
19-(4-chlorophenyl)-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; under 760.051 Torr;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: C₂₈H₃₁ClN₂O₃

: 1165793-60-1
19-phenyl-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

: 1165793-61-2
19-(4-chlorophenyl)-18-cyclohexyl-10-methyl-11,11-dioxo-11λ6-thia-1,4,10,12-tetraaza-tricyclo[12.5.2.0(17,20)]henicosa-14(21),15,17(20),18-tetraene-3,13-dione

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

2: Hoveyda-Grubbs catalyst first generation / 1,2-dichloro-ethane / 15 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 760.05 Torr

With Hoveyda-Grubbs catalyst first generation; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.097