4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

Base Information

Chemical Name:4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile
CAS No.:1438425-43-4
Molecular Formula:C₃₅H₃₃ClN₂O₄Si
Molecular Weight:609.197
Hs Code.:

Synonyms:4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

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Chemical Property of 4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

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Technology Process of 4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

There total 5 articles about 4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1438425-42-3
3-chloro-4-(4-cyano-2-methoxyphenoxy)-N-hydroxybenzenecarboximidoyl chloride

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 1438425-43-4
4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

Guidance literature:: With copper(ll) sulfate pentahydrate; potassium hydrogencarbonate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.04.035

Reference yield:

: 34328-61-5
3-Chloro-4-fluorobenzaldehyde

: 1438425-43-4
4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 95 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1.5 h / 20 °C / Cooling

3: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4: sodium L-ascorbate; copper(ll) sulfate pentahydrate; potassium hydrogencarbonate / water; tert-butyl alcohol / 1 h / 20 °C

With N-chloro-succinimide; copper(ll) sulfate pentahydrate; hydroxylamine hydrochloride; potassium hydrogencarbonate; caesium carbonate; sodium L-ascorbate; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.035

Reference yield:

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 1438425-43-4
4-{2-chloro-4-[5-(2-tert-butyl(diphenyl)silyloxyethyl)-1,2-oxazol-3-yl]phenoxy}-3-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 95 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium hydroxide / water; ethanol / 1.5 h / 20 °C / Cooling

3: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4: sodium L-ascorbate; copper(ll) sulfate pentahydrate; potassium hydrogencarbonate / water; tert-butyl alcohol / 1 h / 20 °C

With N-chloro-succinimide; copper(ll) sulfate pentahydrate; hydroxylamine hydrochloride; potassium hydrogencarbonate; caesium carbonate; sodium L-ascorbate; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.035