2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

Base Information

Chemical Name:2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid
CAS No.:341519-86-6
Molecular Formula:C₂₇H₁₉NO₅
Molecular Weight:437.452
Hs Code.:

Synonyms:2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

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Chemical Property of 2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

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Technology Process of 2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

There total 13 articles about 2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 341519-85-5
2-{4-(tert-butyl-dimethyl-silanyl)-1-[3-methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

: 341519-86-6
2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.3987/com-00-s(i)58

Reference yield:

: 1144-74-7
4-nitrobenzophenone

: 341519-86-6
2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 45 percent / EtMgBr

2: 78 percent / NaOH; tetrabutylammonium iodide / benzene; H₂O

3: 72 percent / LiEt₃BH / tetrahydrofuran

4: 85 percent / PDC / CH₂Cl₂

5: 60 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

6: 94 percent / TBAF / tetrahydrofuran

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 2-methyl-but-2-ene; ethylmagnesium bromide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.3987/com-00-s(i)58

Reference yield:

: 612-14-6
phthalyl alcohol

: 341519-86-6
2-{(Z)-1-[3-Methoxy-3-(4-nitro-phenyl)-3-phenyl-prop-1-ynyl]-but-1-en-3-ynyl}-benzoic acid

Guidance literature:: Multi-step reaction with 12 steps

1: 65 percent / NaH / tetrahydrofuran

2: 79 percent / PDC / CH₂Cl₂

3: tetrahydrofuran

4: CrO₃; H₂SO₄ / acetone

5: 45 percent / Zn / tetrahydrofuran

6: 74 percent / MsCl; Et₃N / CH₂Cl₂

7: 45 percent / EtMgBr

8: 78 percent / NaOH; tetrabutylammonium iodide / benzene; H₂O

9: 72 percent / LiEt₃BH / tetrahydrofuran

10: 85 percent / PDC / CH₂Cl₂

11: 60 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

12: 94 percent / TBAF / tetrahydrofuran

With chromium(VI) oxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; dipyridinium dichromate; 2-methyl-but-2-ene; sulfuric acid; ethylmagnesium bromide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium triethylborohydride; methanesulfonyl chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; benzene;
DOI:10.3987/com-00-s(i)58