(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

Base Information

Chemical Name:(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester
CAS No.:937376-19-7
Molecular Formula:C₁₅H₂₂N₂O₄
Molecular Weight:294.351
Hs Code.:

Synonyms:(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

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Chemical Property of (1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

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Technology Process of (1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

There total 3 articles about (1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 79-24-3
Nitroethane

: 479423-39-7
4-methylbenzaldehyde N-(tert-butoxycarbonyl)imine

: 937376-19-7
(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

Guidance literature:: Nitroethane; With C₂₀H₂₀CuN₂O₄; 4-methoxy-phenol; In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

4-methylbenzaldehyde N-(tert-butoxycarbonyl)imine; In tetrahydrofuran; at -40 ℃; for 40h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja100514y

Reference yield: 90.0%

: 79-24-3
Nitroethane

: 743430-45-7
(E)-tert-butyl 4-methylbenzylidenecarbamate

: 937376-19-7
(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

Guidance literature:: Nitroethane; With para-tert-butylphenol; samarium(III) isopropoxide; chiral Cu-catalyst; In tetrahydrofuran; at -40 ℃; for 1h;

(E)-tert-butyl 4-methylbenzylidenecarbamate; In tetrahydrofuran; at -40 ℃; for 48h; Further stages.;
DOI:10.1021/ja0701560

Reference yield:

: 79-24-3
Nitroethane

: 743430-45-7
(E)-tert-butyl 4-methylbenzylidenecarbamate

: (1S,2S)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

: 1001022-97-4
(1S,2R)-1-(4-methylphenyl)-2-nitropropyl-carbamic acid tert-butyl ester

: (1R,2S)-1-(4-methylphenyl)-2-nitropropyl-carbamic acid tert-butyl ester

: 937376-19-7
(1R,2R)-2-nitro-1-(p-tolyl)propylcarbamic acid tert-butyl ester

Guidance literature:: With 4 A molecular sieve; chiral Me₂NC(O)-CH(t-Bu)-NHC(S)NH-[2-(AcHN)cyclohexyl]; N-ethyl-N,N-diisopropylamine; In toluene; at 4 ℃; for 18h; Title compound not separated from byproducts;
DOI:10.1002/anie.200461814