1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

Base Information

Chemical Name:1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile
CAS No.:131911-42-7
Molecular Formula:C₃₁H₃₂F₂N₂O₃
Molecular Weight:518.603
Hs Code.:

Synonyms:1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

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Chemical Property of 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

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Technology Process of 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

There total 5 articles about 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 135256-92-7
α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

: 131911-42-7
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

Guidance literature:: With potassium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00114a009

Reference yield:

: 37742-99-7
4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile

: 131911-42-7
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, RT, 3 h, 2.) DMSO, 60 deg C, overnight

2: 70 percent / KHCO₃ / CH₂Cl₂ / Heating

3: 85percent aq. hydrazine / Heating

4: 52 percent / K₂CO₃, KI / butan-1-ol / Heating

With sodium hydride; potassium carbonate; potassium hydrogencarbonate; hydrazine hydrate; potassium iodide; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 111952-52-4
α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidineacetonitrile

: 131911-42-7
1-[3-(4-acetyl-2-methoxyphenoxy)propyl]α,α-bis(4-fluorophenyl)-3-pyrrolidinepropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / KHCO₃ / CH₂Cl₂ / Heating

2: 85percent aq. hydrazine / Heating

3: 52 percent / K₂CO₃, KI / butan-1-ol / Heating

With potassium carbonate; potassium hydrogencarbonate; hydrazine hydrate; potassium iodide; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00114a009