N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1321619-04-8
Molecular Formula:C₃₀H₁₈F₂N₄O₄
Molecular Weight:536.494
Hs Code.:

Synonyms:N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Suppliers and Price of N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 4 articles about N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

: 868171-67-9
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1336879-45-8
3-fluoro-4-((5-phenylfuro[2, 3-d]pyrimidin-4-yl)oxy)aniline

: 1321619-04-8
N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.038

Reference yield:

: 873306-25-3
4-chloro-5-phenylfuro[2, 3-d]pyrimidine

: 1321619-04-8
N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.038

Reference yield:

: 10428-49-6
β-chloro-β-nitrostyrene

: 1321619-04-8
N-(3-fluoro-4-(5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluoro phenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 120 °C / Inert atmosphere

2: trichlorophosphate / 0.5 h / 100 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.038